Hepatitis C virus P7
Check Prices A brand new and ever more powerful strain of the Virus was released in to replace the entire B Series line-up. First up is the flag-ship desktop module, the Virus C. Polyphony is expanded from 24 to 32 voices! Otherwise the synth engine is virtually the same as the B series.
Access Virus C / Indigo 2
Ion-channel activity and virus infection Contact us via contact synthelis. Product description Hepatitis C virus p7 HCV p7 protein is involved in the viral life cycle including virus assembly and infectivity. The p7 protomer is able to oligomerize to a hexameric and heptameric state forming an ion channel.
Protein Source: HCV p7 wild type protein serotype 1a. Amino Acid sequence: Histidine tag fused to the N-terminal of the protein. Production conditions: HCV p7 is expressed in a cell-free expression system in the presence of lipid vesicles. Quality analysis Purity: Purification procedure: As standard, HCV p7 proteoliposomes are purified on a sucrose gradient.
Further purification steps can be added if required. HCV p7 proteoliposome after purification Coomassie Blue quantification and Western blot identification. Recombinant proteoliposomes containing HCV p7 have been shown to be active into liposomes using patch clamp recordings. Contact us via contact synthelis. FTIR Spectra of p7 proteoliposomes. Spectrum and fit of cell-free expressed p7 proteoliposomes Fit: Formulation Buffer: Available in Tris 50mM, pH 7.
Others buffers or customized formulation can be provided upon request. Customized Hydrophobic matrix: Customized formulation. Specific lipids can be used upon request. Aliquot for storage. Do not freeze-thaw after aliquoting. Use restrictions: For life science research use only. Available sizes: We observed that p7 channel activity was decreasing immediately after addition of HMA. At 1 mM HMA concentration yellow , we noticed a full blockage of the channel.
Effect of the HMA on p7 protein. Different concentrations of HMA were applied to the bilayer containing p7. Conclusion Our data support the concept of cell-free expression as an efficient and powerful system for the production of proteoliposomes with embedded functional membrane proteins. Biophysical and electrophysiological experiments showed the proper folding of the recombinant protein as well as its associated channel-like activity.
Moreover, our results demonstrate that membrane proteins used as proteoliposomes are easily compatible with a large range of electrophysiological techniques e. Finally, p7 protein expressed in a proteoliposome format is ready to be used for high-throughput screening of inhibitors in order to develop new drugs for HCV therapy.
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The Access Virus employs various synthesis techniques, including subtractive synthesis , phase distortion PD synthesis , frequency modulation FM synthesis , and starting with the TI series, wavetable synthesis. All of the Viruses are DSP -powered, virtual analog synthesizers. They have analog-style oscillators which can be tuned continuously from a pure sine wave to a square wave with variable pulse-width modulation , as well as 63 “spectral” waveforms which are entirely synthetic, non-analog style waves. Oscillator waveforms may be modulated in a number of ways: The Virus has a Matrix Modulation specification. With the TI series, two new oscillator models were added: Hypersaw and wavetable.
VIDEO: Access Virus C | Vintage Synth Explorer
Access Virus Version C Desktop Synth. 32 knobs. 35 buttons. voice polyphony. museum soundtracks, the Virus C Desktop Synth is heir to a legendary line of predecessors, and it inherits their incredible musical traditions with flying colors. I’ve had a Virus C for years and I’ve tried to read the manual a bunch of times to figure out the MultiTimbral aspects of the synth. Does anyone.